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Isoniazid CAS#54-85-3

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  • Isoniazid CAS#54-85-3
  • Isoniazid CAS#54-85-3
  • Isoniazid CAS#54-85-3
  • Isoniazid CAS#54-85-3
  • Isoniazid CAS#54-85-3

›

Isoniazid CAS#54-85-3

Excellent Stability and Water Solubility: Isoniazid is chemically stable and readily soluble in water, supporting convenient formulation and broad application use.


Strong Reducing Properties: The hydrazine group provides excellent reducing capability, enabling reactions such as the conversion of dissolved oxygen to hydrogen peroxide under alkaline conditions.


Versatile Chemical Reactivity: Its active amino group (-NH₂) allows efficient reactions with carbonyl compounds, carboxylic acid derivatives, and sulfonyl chlorides, making it a valuable intermediate for derivative synthesis.


Suitable for Analytical and Luminescent Systems: It can participate in gold nanoparticle-catalyzed luminol luminescent systems, offering potential advantages in analytical and detection applications.


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Product Description

Product Description of Isoniazid CAS#54-85-3

Isoniazid is colorless or white crystalline powder with slight bitterness, stable and easily soluble in water.

Its hydrazine group has strong reducibility, capable of reducing dissolved oxygen under alkaline conditions for luminescent analysis use. Its amino group enables reactions to synthesize Schiff bases and various isoniazid derivatives.


Product Application of Isoniazid CAS#54-85-3

Isoniazid is a first-line, affordable anti-tuberculosis drug with high efficacy and low toxicity, also used as electroplating additive and chemical intermediate.
It can undergo condensation reactions to form multiple derivatives with anti-tuberculosis effects. Isoniazid shows the strongest potency, while its hydrazone has weaker antibacterial action yet lower neuro and hepatic toxicity.
It features strong selective inhibition against tubercle bacilli, achieving bacteriostasis at low concentrations and sterilization at higher doses for clinical and research use.

Product Information

Parameters


Melting point171-173 °C (lit.)
Boiling point251.97°C (rough estimate)
density1.2620 (rough estimate)
bulk density800kg/m3
refractive index1.6910 (estimate)
Fp>250°C
storage temp.2-8°C
solubility125g/l
formCrystals or Crystalline Powder
pkapKa 2.00/3.60/10.8(H2O) (Uncertain)
colorWhite or colorless
PH6-8 (50g/l, H2O, 20℃)
OdorOdorless
PH Range5.5 - 6.5 at 10 g/l at 25 °C
Water Solubility14 g/100 mL (25 ºC)
SensitiveAir Sensitive
Merck145186
BRN119374
BCS Class1,3
Stability:Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
InChIKeyQRXWMOHMRWLFEY-UHFFFAOYSA-N
CAS DataBase Reference54-85-3(CAS DataBase Reference)
NIST Chemistry ReferenceIsoniazid(54-85-3)
IARC3 (Vol. 4, Sup 7) 1987
EPA Substance Registry SystemIsoniazid (54-85-3)


Safety Information


Hazard CodesXn
Risk Statements22-38-40-36/37/38
Safety Statements37-36/37/39-26
RIDADR2811
WGK Germany3
RTECSNS1751850
TSCAYes
PackingGroupIII
HS Code29333999
Hazardous Substances Data54-85-3(Hazardous Substances Data)
ToxicityLD50 in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer)


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